Creatinine Clearance Calculator (Cockcroft-Gault Equation)
Estimates Creatinine Clearance (CrCl in mL/min) for renal drug dose adjustment across adult patients.
⚠️ Educational Calculation & Clinical Safety Safeguard: Cockcroft-Gault requires stable serum creatinine; do not rely on a single SCr value during acute kidney injury (AKI). Educational calculations do not replace clinician assessment, patient-specific laboratory monitoring, or institutional prescribing protocols.
Interactive Calculator
Allowed physiological/compounding range: 18 to 110 years
Allowed physiological/compounding range: 25 to 250 kg
Allowed physiological/compounding range: 0.2 to 20 mg/dL
Allowed physiological/compounding range: 0 to 1 1=Male, 0=Female
Calculated Output (mL/min)
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Step-by-Step Mathematical Derivation & Explanation:
Validated Formula & Conversion Rules
CrCl (mL/min) = [(140 − Age) × Weight (kg)] / [72 × SCr (mg/dL)] × (0.85 if Female)Worked Clinical Example
65-year-old Male, Weight 72 kg, SCr 1.5 mg/dL: CrCl = [(140 − 65) × 72] / (72 × 1.5) = 75 / 1.5 = 50.0 mL/min.
Rounding Rules, Assumptions & Source References
- Rounding Rule: Round CrCl to nearest whole mL/min or 1 decimal place.
- Clinical Assumptions & Limitations: Validated only within the stated physiological input boundaries. For paediatric, renal (Cockcroft-Gault), and critical-care infusion calculations, always cross-check against official product labelling and institutional guidelines.
- Source References: Indian Pharmacopoeia (IP 2022), National Formulary of India (NFI), British National Formulary (BNF), and NCBI Bookshelf Clinical Pharmacology Compendia.